Cross-elicitation responses to 2-methoxymethyl-p -phenylenediamine in p -phenylenediamine-allergic individuals: Results from open use testing and diagnostic patch testing

Cross-elicitation responses to 2-methoxymethyl-p-phenylenediamine under hair dye use conditions in p-phenylenediamine-allergic individuals.

BACKGROUND The factors influencing elicitation responses in individuals allergic to p-phenylenediamine (PPD) in hair dyes are not well understood. OBJECTIVES Investigation of the elicitation response to the new, less-sensitizing PPD alternative 2-methoxymethyl-p-phenylenediamine (ME-PPD) under simulated hair dye use conditions. METHODS The cross-elicitation response to ME-PPD (2% in a hair ...

Monitoring contact sensitization to p-phenylenediamine (PPD) by patch testing with PPD 0.3% in petrolatum.

BACKGROUND Being a contact allergen of general relevance, p-phenylenediamine (PPD) is patch tested in the baseline series. However, PPD 1% in petrolatum may actively sensitize. Patch testing with PPD at 0.35% pet. proved to be safe, as far as active sensitization is concerned. OBJECTIVES To determine whether PPD 0.3% pet. reliably detects PPD sensitization. METHODS Patch testing with PPD 0....

Positive relationship-intensity of response to p-phenylenediamine on patch testing and cross-reactions with related allergens.

BACKGROUND Hair dye exposure is the most common cause of sensitization to p-phenylenediamine (PPD). Cross-reactions with structurally related allergens occur. OBJECTIVES It is suggested that a stronger patch test reaction (3+ rather than 1+) to PPD (usually tested as 1% petrolatum) is associated with an increased propensity for cross-reactions. In this article we will demonstrate this associa...

Influence of vitamin C on the elicitation of allergic contact dermatitis to p-phenylenediamine.

BACKGROUND Hair dyes represent one of the most important causes of allergic contact dermatitis resulting from the use of cosmetic products. The principal causative chemistry is associated with oxidation products of p-phenylenediamine (PPD) and closely related substances. OBJECTIVES To examine whether prior application of the antioxidant vitamin C to the skin was able to reduce the cutaneous a...

University of Groningen P - phenylenediamine